WHO suggestions mandate that sterility test isolators go through complete revalidation at least every year, or even more regularly if sizeable modifications or upkeep actions have happened. The DPTE® technique delivers egress from inside the isolator chamber while protecting isolator integrity; there's no danger of sample or environmental contamination. https://tailinscitech.wixsite.com/tailinscitech/post/applications-and-benefits-of-tailin-containment-isolator-for-handling-high-potency-materials