Induction of microsomal enzymes by this drug, might shorten the half-life of doxycycline for as long as 2 months just after barbiturate therapy discontinued; observe clinical response to doxycycline intently if both drugs administered concurrently pentobarbital will reduce the extent or impact of diltiazem by affecting hepatic/intestinal enzyme CYP3A4 metabolism. https://georged493pye5.sasugawiki.com/user