Here, we display that conolidine, a pure analgesic alkaloid used in conventional Chinese medication, targets ACKR3, therefore giving more evidence of the correlation between ACKR3 and discomfort modulation and opening substitute therapeutic avenues for the procedure of Long-term soreness. The primary asymmetric overall synthesis of conolidine was formulated by https://luisr738lds3.bmswiki.com/user