In this article, we show that conolidine, a pure analgesic alkaloid Utilized in classic Chinese drugs, targets ACKR3, thereby offering supplemental evidence of the correlation among ACKR3 and ache modulation and opening option therapeutic avenues to the therapy of Long-term soreness. The primary asymmetric total synthesis of conolidine was https://proleviate-nature-s-pain43097.total-blog.com/the-5-second-trick-for-conolidine-57776429