Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals within the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific tests have recognized recurrent mutations in genes regulating tumor cell-microenvironment intera... https://jasonc851hko2.bligblogging.com/profile