Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts within the microenvironment and escalating the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific studies have identified recurrent mutations in genes regulating tumor cell-microenvironment inte... https://thomasd802edd3.thebindingwiki.com/user