Hallucinogens/psychedelics can also be connected to novel mechanisms of action in relation to conventional medications, that happen to be normally according to the monoaminergic imbalance concept. The modulation of cortical five-HT2A receptors and the subsequent increase in glutamatergic tone along with the linked neuroplasticity are novel mechanisms of action.seven,forty one,60 https://www.evernote.com/shard/s719/sh/330863cc-f66e-28c9-1f41-da0804b81796/RMpoTb0riW3RmWT16RjoS367Hafssl_5BT2tyYmOPBlf01wp-Yuv0jPVlw